Most common Medications for Hyperemesis Gravidarum

Medications to treat Hyperemesis Gravidarum Nausea and vomiting in pregnancy. Here a list from my website that I need to update . However I want to share all information from the HER Foundation as I volunteer for them and one of the Co founders are my best friend and HG sister .

I use there website to go off of and any of my latest research or medical conferences I reference any of the latest informational research.

It’s okay to admit you need medication, your not weak or just overreacting. Hyperemesis Gravidarum needs to be treated aggressively and early. Below are a list of medications that the HER FOUNDATION go by I am working on added this in a whole separate section on my website and putting it in my blog until then . Below is a list if you have any questions please comment so I can help answer your questions.


Helps Nausea & Vomiting

  • It is taken 4 to 8 mg every 6 hours. Can be given via SQ pump, oral tablet, liquid, dissolve film, or IV. Suppository available outside US.
  • Can be compounded into a suppository or other form.
  • Dosing throughout pregnancy may prevent relapse or stabilize symptoms.
  • Zofran tablets are available as a generic. NEW UPDATE ZOFRAN IS SAFE TO TAKE !
  • Widely available around the world.
  • Proactively treat with a daily regimen of stool softeners and laxatives as needed.
  • Some report generic oral dissolvable tablets do not dissolve as well.

Kytril, Sancuso (Granisetron)

Helps Nausea & Vomiting

  • Kytril, Sancuso, Granisetron are being used more for HG when Zofran fails.
  • 1 mg every 12 hours (IV or orally)
  • Allows twice a day dosing.
  • Also available in transdermal patch form
  • Medication For The Battery Acid Heartburn:
  • Zantac
    • (Ranitidine) 50 mg IV every 8 hours or 150 mg orally daily or twice a day


    • (Famotidine) 20 mg IVP/or orally every 12 hours
    • IV is more affective.


    (Lansoprazole) 30-60 mg/day


    Cortisone/Corticosteroids – Not recommended until after 8-10 weeks, however, the benefit may outway the risk, please talk with your doctor if you are very sick.

    Can cause birth defects if used earlier but has helped many HG mothers with extreme HG symptoms

    – Used for refractory Hyperemesis Gravidarum, usually in conjunction with Ondansetron/Zofran

    – Possible side-effects: blood sugar instability, weight loss, nausea and vomiting, increased risk of preeclampsia

    – Possible fetal complications: reduced birth weight, clefts (if early use), adrenal insufficiency (if exposed to large doses)

    – Inconclusive concerns over impact on fetal brain development and oral/lip clefts with prolonged dosing at high levels, and use during the first trimester


    comes in pill form for HG has not been determine

    also works intravenous. Helps Nausea and vomiting in some case studies.

    Medications that have not been fully study in HG women fully. Some studies going on now.

    Gabapentin (Neurontin):

    In trials for use in HG. Considered as last resort in patients who have exhausted other medication categories. There are some facebook groups with mothers trying this, message if you need a link.

    Medications that can help HG

    It really depends on how sick you are with HG. There are many types of medications as there are different levels of HG. Every mother is different so what works for one may not work for the other. If one doesn’t work, keep trying to find a combo that works, it may be 2-4 different kinds. There are many treatments that can ease HG symptoms, it won’t take away all of HG but it’s important to have a good doctor and a advocate to help speak for you. Many mothers are to sick and weak to fight for good health care. Below is a list of medications that can help before having to ask for home health care.

    Compazine, Stemetil


    Nausea & Vomiting

    5–10 mg orally, IM, or IV every 6–8 hours

    ( Burns in the IV pretty bad, I.M. injection burns too)

    25 mg every 6–8 hours rectal Risk of EPS increased with metoclopramide

    Reglan- 10–20 mg IV/orally every 6 hours

    May be given orally, SQ pump, IV (SLOWLY)

    in pill form 5-10 MG 1-4 X a day

    In IV piggy backed for 15 minutes on IV fluids


    12.5–25 mg IVP/orally, IM/PR every 4-6 hours

    *IV dose contains sulfite

    NEW Research Warning from HELP HER: IV or injected doses can cause tissue damage. More info available on GIVE IV dose SLOWLY to avoid contractions.

    Side-effects of anxiety, sedation, and restlessness common and may limit use.



    Oral/IM 12.5–25mg every 4–6 hours

    Rectal 50–100 mg every 6–8 hours May increase risk of fetal malformations.

    May cause muscle spasms in neck/face and/or difficulty with speech. Research articles on PubMed.


    (Haloperidol) 1–2 mg orally/IM every 8 hours Extrapyramidal symptoms (EPS) more common. May cause constipation. Research articles on PubMed.


    Bonine, Antivert, Marezine


    Follow directions on the label.



    -50-100 mg every 4-6 hours Used for motion sickness.


    -25 mg orally at bedtime,

    1/2 tablet every 6 hours as needed Component of Diclegis/Diclectin.

    UNISOM is often taken with

    vitamin B6 they now have it as a pill combined as a pill and gos by the names

    Diclectin, Diclegis

    Doxylamine plus pyridoxine

    Average dose is 1 tablet in morning, one in afternoon and two at night. May be given in higher doses up to 12 tablets daily – see research links on right. Differs from Unisom/B6 combo because it isa delayed release formula.

    Ondansetron also known as Zofran works for some HG mothers compared to Doxylamine andpyridoxine (Diclegis/Diclectin) for treatment of nausea in pregnancy the return to the USA of doxylamine-pyridoxine delayed release combination Diclegis® was made for morning sickness and morning sickness and HG are NOT one and the same and many medical doctors are still learning this. For some women this works and some it doesn’t . They took the B6 and Unisom and made it into one pill called Diclegis . Some HG mothers that have light HG said it helped and mothers with severe HG nothing helps.


    (Diphenhydramine or Gravol) 25 mg IVP/orally every 4–6 hours

    Benadryl and Phenergan combined in an IV helps many HG mothers relax and sleep for a short time to have a reprieve, or Zofran and Benadryl both at the sametime.


    (Trimethobenzamide) 25 mg orally every 6-8 hours

    200 mg IM every 6-8 hours

    Vistaril, Atarax

    (Hydroxyzine) 25 mg orally every 6 hours Syrup available

    Helpful for insomnia

    Benadryl and Zofran combo : Sometime the two medications together can help a HG mother fall asleep for a bit to stop the vomiting.

    25-50 mg of IV Benadryl slow push or piggy back it hanging with hydration.

    4 -8 ml of Zofran

    When treatment fails …..

    alternative medication has helped so many moms this blog post I really like I know the mom who wrote it off Twitter

    Click Below :


    This news story is a great one too !

    Hyperemesis Gravidarum, All Day And Night Sickness, this is not just Morning Sickness it’s beyond ……….

    If you need a list to more medications please let me know and I’ll do my best to help you !

    Sister Starr Andrews Strong HG Activist


    List Courtesy of more information on the Her Foundation visit HelpHer.Org